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Dysregulation of this axis leads to a self-perpetuating cycle of inflammation, oxidative stress, and tissue damage

10.3945/jn.116.230912 J Nutr

American Cancer Society

In addition, the activities of glyceraldehyde-3-phosphate dehydrogenase, methionine synthase and the PAPS reductase are inhibited by S -glutathionylation in E

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Therefore, MMP-9 plays a crucial double-edged sword role in lung injury: early overactivation exacerbates acute inflammatory damage and barrier destruction, while persistent dysregulation in the later stage becomes an important molecule promoting the transformation from inflammation to fibrosis